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Alex Singleton makes key play in first game back after testicular cancer diagnosis


In his first game back after announcing he was diagnosed with testicular cancer, Broncos linebacker Alex Singleton came up with a big defensive play late in a thrilling “Sunday Night Football” showdown between the Commanders and Denver. 

The instance came in the final minutes of regulation with the Broncos clinging to a 20-17 lead and Washington quarterback Marcus Mariota went for a deep pass on third-and-21 to Zach Ertz. 

Broncos inside linebacker Alex Singleton (49) breaks up a pass intended for Washington Commanders tight end Zach Ertz (86) during the second half of an NFL football game Sunday, Nov. 30, 2025. AP

Ertz looked as though he was going to pull the pass in, but just in the nick of time, Singleton was able to get his hands on the ball and knock it away to force fourth down. 

Singleton, who has been dealing with quite a bit since the cancer diagnosis, raised his hands in the air in celebration as the crowd in Denver roared. 

The Commanders were forced to punt, but they did manage to tie the score and force overtime, where the Broncos managed to pull out the win thanks to a 5-yard touchdown run by RJ Harvey.

The Broncos stopped Washington’s two-point conversion attempt to seal the win.

Singleton added a key pass pressure on Washington’s possession in overtime.

Broncos linebacker Alex Singleton (49) breaks up a pass intended for Washington Commanders tight end Zach Ertz (86) in the fourth quarter of the game at Northwest Stadium. IMAGN IMAGES via Reuters Connect

Singleton’s return on Sunday night was a miraculous one, considering how recently he was diagnosed with cancer and a mere three weeks after he underwent emergency surgery for his testicular cancer. 

He had shocked the NFL world when he announced earlier this month that a random NFL drug test had detected the signs of cancer and that he would be undergoing surgery. 

“Thankfully, we believe the cancer was caught early with a great prognosis for me and my family,” he said in a statement at the time. “While we are still awaiting some additional test results, I fully expect to return to the field in the coming weeks.”

Broncos LB Alex Singleton (49) returns to the lineup after testicular cancer surgery. NBC

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In a separate media session with local reporters, he indicated that he wouldn’t be out too long. 

“I’m not giving an exact timetable yet, but I should recover pretty quickly from this surgery and get up and running here pretty soon,” Singleton said. “… I was able to not have as invasive of surgery. … It feels good that optimistically, it’s not going to be four, five, six weeks, thankfully.”

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